Nikki Glaser, the comedian who hosted the 82nd Golden Globe Awards, delivered a memorable opening monologue filled with witty jabs and playful humor. As the host, Glaser had the tough task of keeping the audience engaged while balancing the art of comedy with respect for the guests in the room. Although her jokes were sharp, they never crossed the line into being overly harsh. Here’s a breakdown of some of the best and funniest moments from her 10-minute monologue.

Glaser kicked off the show with a funny remark about the event’s atmosphere. She opened by saying, “Welcome to the Golden Globes, Ozempic’s biggest night!” The mention of Ozempic, a medication that’s recently gained attention for weight loss, instantly grabbed the audience’s attention. Glaser joked that she had finally “made it” by being at the Beverly Hilton, but humorously noted that this time she was fully dressed. It was a perfect start to her night of jokes, blending self-deprecation with the kind of humor that made her such a popular choice for hosting.

One of the most memorable parts of Glaser’s opening remarks was when she poked fun at the political influence of celebrities. She said, “I’m not here to roast you. And how could I? You’re all so famous, so talented, so powerful. I mean, you could really do anything — except tell the country who to vote for. But it’s okay. You’ll get them next time!” The playful jab at Hollywood’s political involvement was met with laughter, as Glaser captured the complex relationship between fame and activism in a lighthearted way.

Later, she made a cheeky joke about Ben Affleck and the movies nominated that evening. “Wicked, Queer, Nightbitch — these are not just words Ben Affleck yells after he orgasms. These are some of the incredible movies nominated tonight.” The comment, although a bit edgy, was clearly meant to be playful, and it got a great reaction from the crowd. Glaser had a unique way of balancing sharp humor with genuine respect for the movies being recognized that night.

Zendaya, another favorite at the awards, was also the target of a few jokes. Glaser praised her performance in Dune, saying, “I woke up for all of your scenes.” She also teased Zendaya’s other movie, Challengers, calling it more sexually charged than Diddy’s credit card. It was a humorous way to compliment Zendaya while making light of the buzz surrounding her roles. Glaser’s comment about the after-party, humorously mentioning how it wouldn’t be as good this year, added to the playful tone of the monologue.

At one point, Glaser addressed the television networks where the show was airing. She said, “If you’re watching on CBS, hello. If you’re watching this on Paramount+ you have six days left to cancel your free trial.” It was a clever, timely jab at the ever-growing streaming wars, with Glaser’s delivery making it feel less like an advertisement and more like a well-timed joke.

Another funny moment came when Glaser pointed out the hard-working actors in the room—by which she meant the servers. The line was a funny contrast, as she acknowledged the unseen work that goes on behind the scenes during such a glamorous event. It was a clever way to include everyone in the room, even those not on the stage.

Glaser also couldn’t resist making a joke about Timothée Chalamet, who was nominated that evening. “Tilda Swinton is, of course, nominated this year for her role as Timothée Chalamet,” Glaser joked. The audience was in stitches as she continued, commenting on Chalamet’s iconic look, specifically his “gorgeous eyelashes” and his portrayal of Bob Dylan in A Complete Unknown. She cheekily noted that even Bob Dylan himself had admitted that Chalamet’s singing voice was “absolutely horrible.”

As the monologue continued, Glaser shifted gears and shared a funny story about her own high school experience with Wicked, the popular musical. She shared how much she loved the show, just like her friends, her boyfriend, and even her boyfriend’s boyfriend. This quirky and funny personal touch made the audience feel like they were getting to know Glaser a little better while still keeping things lighthearted.

In a playful dig at two of the night’s most anticipated films, Wicked and Joker 2, Glaser made a funny comparison. She joked that in Wicked, some people complained the movie was ruined by people singing, while in Joker 2, people complained that the movie was ruined by “the images on the screen and the sounds that accompanied them.” It was a humorous take on how both movies received mixed reviews, but it was all in good fun.

When it came to Harrison Ford, Glaser didn’t hold back either. She shared an amusing exchange where she asked the legendary actor if he would rather work with Zendaya or Ariana Grande. Ford’s response? “Indica.” The audience burst into laughter at Glaser’s perfect delivery and the unexpected punchline.

As the night went on, Glaser continued her witty commentary, including a playful reference to Robert F. Kennedy Jr. and the various television shows nominated that evening. Her comment about The Bear, The Penguin, and Baby Reindeer being “not just things found in R.F.K.’s freezer” was a sharp, yet playful jab, which once again balanced her comedy with respect for the event’s tone.

Nicole Kidman also got her share of attention, with Glaser acknowledging her impressive 20 Golden Globe nominations. Glaser jokingly thanked Keith Urban for playing guitar around the house so much that it led Kidman to “make 18 movies a year.” It was a funny and light-hearted way to pay tribute to Kidman’s dedication to her craft.

Finally, Glaser ended her monologue with a joke about the unpredictability of the night. She joked that years from now, people would watch clips from this very event on YouTube and spot someone in the crowd who would later become infamous. The punchline was a clever nod to the fact that anything can happen, even at an event as glamorous as the Golden Globes.